Table 2 The moderation effect of the rs6265 polymorphism on the relationship between the childhood trauma questionnaire (CTQ) and the posttraumatic stress disorder checklist (PCL) score while controlling for gender, age, years of education, lifetime events checklist (LEC), hospital anxiety and depression scale (HADS), insomnia severity index (ISI), and alcohol use disorders identification test (AUDIT).

From: Influence of childhood trauma and brain-derived neurotrophic factor Val66Met polymorphism on posttraumatic stress symptoms and cortical thickness

Variables

B

S.E.

t

R 2

Model 1

(Constant)

−30.525

10.331

−2.955**

0.355***

gender

−4.329

2.336

−1.854

 

age

−0.203

0.085

−2.408*

 

years of education

−1.212

0.359

−3.376**

 

LEC

2.353

0.512

−3.376***

 

rs6265

12.375

6.553

1.888

 

CTQ

0.480

0.109

4.384***

 

rs6265 × CTQ

−0.326

0.128

−2.548*

 

rs6265

Effect

Boot S.E .

Boot Confidence Interval

CC (Val/Val)

0.480***

0.109

[0.264, 0.695]

CT & TT (Met allele)

0.154

0.085

[−0.013, 0.321]

Model 2

(Constant)

−8.607

7.073

−1.217

0.757***

gender

0.949

1.659

0.572

 

age

−0.098

0.055

−1.781

 

years of education

−0.220

0.231

−0.952

 

LEC

0.882

0.331

2.662**

 

HADS - anxiety

1.487

0.234

6.361***

 

HADS - depression

1.030

0.242

4.257***

 

ISI

0.612

0.122

5.028***

 

AUDIT

−0.284

0.218

−1.304

 

rs6265

7.690

4.107

1.872

 

CTQ

0.236

0.070

3.375**

 

rs6265 × CTQ

−0.161

0.081

−1.988*

 

rs6265

Effect

Boot S.E .

Boot Confidence Interval

CC (Val/Val)

0.236***

0.700

[0.098, 0.374]

CT & TT (Met allele)

0.076

0.053

[−0.029, 0.180]

  1. *p < 0.05, **p < 0.01, ***p < 0.001.