Figure 4 | Scientific Reports

Figure 4

From: Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression

Figure 4The alternative text for this image may have been generated using AI.

Dec2 depletion causes the reduced GFRα1(+) undifferentiated spermatogonia. (a) Gross image of adult testes from wild type and Dec2 knockout mice. WT, wild type; KO, Dec2 knockout. Scale, 5 mm. (b) Testicular weights of WT (n = 5) and KO (n = 3) were measured. (c) Number of GFRα1(+) germ cells were counted in the testicular sections of WT (n = 5) and KO (n = 3). (d) SSC transplantation analysis. Donor-derived H4-Venus(+) colonies were counted eight weeks after transplantation in control (CTR, n = 5) and shDec2 (n = 4) samples. Student’s t-test was performed for statistical analysis. Error bars indicated standard deviations. *p value < 0.05; **p value < 0.01; ***p value < 0.001.

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