Table 2 Gene profile characteristic of GD patients in comparison to controls and NPC patients.

From: Gene expression profile in patients with Gaucher disease indicates activation of inflammatory processes

Comparison

GD patients vs.cControls

GD patients vs. NPC patients

Genes with Changed Expression

UP-regulated

Fold change

UP-regulated

Fold change

SERPINB2

3,675

MX1*

3,139

PLAU

3,242

TMEM158

2,786

IL13RA2*

2,879

UCHL1

2,727

IFI6*

2,769

ISG15

2,637

TXNIP

2,605

PLAU*

2,591

IFIT2

2,568

FOS

2,508

IFIT1

2,555

MLLT11

2,473

NPTX1

2,473

IFIT1

2,384

TMEM158

2,457

PLOD2

2,380

WLS

2,362

IGF2BP3

2,256

DOWN-regulated

Fold change

DOWN-regulated

Fold change

IGFBP5

−4,027

PTGIS

−3,661

CRISPLD2*

−2,689

ATOH8*

−3,150

THBS2

−2,445

MXRA5*

−2,926

ATOH8*

−2,354

MN1*

−2,837

NNMT

−2,323

FOXQ1

−2,743

CNN1

−2,103

CRIP1

−2,648

ISLR

−2,070

COMP

−2,573

C1QTNF5

−2,023

HSPB7

−2,478

CSRP1

−1,998

TSHZ2

−2,414

MYLIP

−1,988

ISLR

−2,250

  1. Results of microarray studies were analysed with IPA program. Genes with changed expression, characteristic of GD patients are bolded and underlined. Genes with asterisks displayed the most remarkable enhancement or inhibition after qRT-PCR analyses.
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