Figure 1
From: CD271 is a molecular switch with divergent roles in melanoma and melanocyte development
CD271 expression has a strong impact on melanoma transcriptome and has distinct effect in melanocytes. (A) Experimental design of patient-derived transcriptomic profiles of CD271+ and CD271− melanoma cells in comparison with profiles of healthy donor melanocytes. All cell populations were sorted by flow cytometry and subjected to transcriptomic profiling. (B) Heat map of gene expression profiles and indication of CD271 status in tumor cells (pink and purple) vs normal melanocytes (grey). Selfrenewal, cell cycle and cell survival pathways are significantly overrepresented with p values below 0.05 in CD271+ melanoma-initiating cells vs CD271− cells and normal melanocytes. Principal component analysis (PCA) reveals separation of expression profiles.
