Table 3 Overview of drugs pre-clinically suggested for ADPKD.
From: Drug prioritization using the semantic properties of a knowledge graph
Identifier | Name | Mechanism of action | Selected recent reference (PMID) |
|---|---|---|---|
UMLS C0077274 | Triptolide | intracellular calcium homeostasis | 24560027 |
UMLS C2975283 | Mozavaptan | Vasopressin V2 receptor antagonist | 27578560 |
UMLS C2607958 | Satavaptan | Vasopressin V2 receptor antagonist | 18945944 |
UMLS C0028833 | Octreotide | Somatostatin receptor agonist | 26844873 |
UMLS C1872203 | Pasireotide | Somatostatin receptor 2 agonist | 24994926 |
UMLS C1174836 | SKI-606 | c-Src inhibitor | 18385429 |
UMLS C1516119 | Sorafenib | Raf kinase inhibitor | 20810616 |
UMLS C0755562 | U0126 | MEK Inhibitor | 18263604 |
UMLS C1831731 | Bosutinib | Src/Bcr-Abl tyrosine kinase inhibitor | 28838955 |
UMLS C0541315 | Everolimus | FK506-binding protein 1 A inhibitor | 25424440 |
UMLS C0072980 | Sirolimus | FK506-binding protein 1 A inhibitor | 29880342 |
UMLS C0025598 | Metformin | Mitochondrial complex I (NADH dehydrogenase) inhibitor | 21262823 |
UMLS C0071097 | Pioglitazone | Peroxisome proliferator-activated receptor gamma agonist | 28191533 |
UMLS C0289313 | Rosiglitazone | Peroxisome proliferator-activated receptor gamma agonist | 28191533 |
UMLS C0536217 | Roscovitine | CDK inhibitor | 23032260 |
UMLS C0025270 | Menadione | Cdc25A | 22155366 |
UMLS C0717758 | Etanercept | TNF-alpha inhibitor | 18552856 |
UMLS C0034283 | Pyrimethamine | Stat3 inhibitor | 21821671 |
ChemSpider 221421 | S3I-201 | Stat3 inhibitor | 21821671 |
UMLS C1718383 | Teriflunomide | Stat3 inhibitor | 22155366 |
UMLS C1957685 | Genz-123346 | glucosylceramide synthase inhibitor | 20562878 |
UMLS C0968934 | HET-0016 | 20-HETE synthesis inhibitor | 19129252 |
UMLS C0916207 | TRAM-34 | KCa3.1 inhibitor | 18547995 |
UMLS C0010467 | Curcumin | Multiple | 21345977 |
UMLS C2935082 | EX-527 | SIRT1-specific inhibitor | 23778143 |
