Figure 6 | Scientific Reports

Figure 6

From: Examination of novel 4-aminoquinoline derivatives designed and synthesized by a hybrid pharmacophore approach to enhance their anticancer activities

Figure 6The alternative text for this image may have been generated using AI.

Compound 13 causes the formation of multiple spindle poles and uneven segregation. (a) HeLa S3 cells were synchronized at G2/M by nocodazole, followed by incubation for 6 h in drug-free medium in the absence (Sham control) or presence of 5 μM of compound 13. Note the presence of uneven cell sizes (arrows) which were likely generated as a result of nondisjuctional chromosome segregation during mitosis. (b) Multiple spindle phenotypes were seen in 44.4% of compound 13-treated cells. In contrast, the untreated control sample contains very few cells with abnormal spindles.

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