Figure 8 | Scientific Reports

Figure 8

From: Examination of novel 4-aminoquinoline derivatives designed and synthesized by a hybrid pharmacophore approach to enhance their anticancer activities

Figure 8The alternative text for this image may have been generated using AI.

Combination of compound 13 and BTZ is highly effective. (a) 2.7–8.0 μM of compound 13 effectively killed cancer cells by 48 h. Asynchronous MCF7 cells were incubated for 48 h in the absence (Sham control) or presence of compound 13 at 2.7 or 8.0 µM. (b) The combination of low doses of compound 13 (0.75 μM) and BTZ (6 nM) shows synergistic effects on Jurkat cells. Asynchronously growing Jurkat lymphoma cells were incubated for 48 h in the absence (sham control) or presence of BTZ ± VR23, followed by cell analysis by cytometry.

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