Figure 1
Overall CpG methylation pattern in obese and control women. (a) Box plot of the methylation profile of endometrial epithelial cells from normal (n = 5) and obese (n = 3) women, together with the profile of stage I endometrial cancer (n = 41). (b) Density plot of the averaged β-values of CpG sites of obese (blue) and normal women (black). (c) Principal component analysis revealed a region for the averaged β-values of CpG sites of obese women (closed circle, dashed line) marked distinctly from those of normal women (open circle). (d) Scatter plot comparing the averaged β-values for individual CpGs between normal and obese cases. Plotted data represent CpG sites that differed in the averaged β-value by at least 0.2.
