Figure 4

Overlap of differentially methylated regions (DMRs) between the obese cases and stage I endometrial cancer. (a) Venn graph showing the overlap of DMRs that were identified in our study and those of stage I endometrial cancer. (b) Shared DMRs are enriched for EB virus and B cell signaling pathways, and the methylation levels of all shared genes are decreased (red) in two pathways. (c) The extent of the decrease in methylation levels in shared DMRs. The extent of decrease in methylation levels in shared DMRs were greater in stage I EC, compared with those of obese women.