Figure 7
CPT and oncolytic MV are cytotoxic against human T-47D breast cancer cells and induce enhanced cell death in combination using the co-treatment model. T-47D cells (104 cells per well) were treated with CPT (1–1000 nM) (A) and/or infected with MV (MOI 0.01, 0.05, 0.1, 0.5, 1, 3, and 10) (B) for 3 or 5 days. Cell viability was analyzed by MTT assay; DMSO = 0.1%. Data shown are means ± SEM (*P < 0.05 compared to Mock treatment) from three independent experiments. In the co-treatment model (C), T-47D cells were treated with MV (MOI 0.1) and CPT (10, 30, and 50 nM). Data shown are means ± SEM (*P < 0.05 compared to MV treatment, and #P < 0.05 compared to CPT treatment) from three independent experiments.
