Table 4 Risk of Alzheimer’s disease by prescribed amount of weak anticholinergic agents.

All subjects (n = 191,805)

overall

13,133 (6.9)

2.17 (2.13–2.21)

0–29

7,217 (6.2)

1.97 (1.92–2.01)

Reference

Reference

Reference

30–119

3,451 (7.9)

2.49 (2.41–2.57)

1.24 (1.19–1.29)

1.09 (1.05–1.14)

1.01 (0.97–1.06)

120–299

1,693 (7.9)

2.51 (2.39–2.63)

1.25 (1.19–1.32)

1.08 (1.03–1.14)

0.97 (0.92–1.03)

≥300

772 (7.5)

2.38 (2.13–2.21)

1.21 (1.12–1.30)

1.09 (1.01–1.17)

0.95 (0.88–1.02)

Young-old subgroup (n = 84,566)

overall

2,542 (3.0)

0.94 (0.90–0.98)

0–29

1,358 (2.5)

0.78 (0.74–0.82)

Reference

Reference

Reference

30–119

699 (3.9)

1.22 (1.13–1.31)

1.53 (1.39–1.67)

1.36 (1.24–1.49)

1.17 (1.06–1.29)

120–299

326 (4.0)

1.24 (1.10–1.37)

1.56 (1.38–1.76)

1.37 (1.21–1.54)

1.09 (0.97–1.22)

≥300

159 (4.1)

1.27 (1.07–1.47)

1.61 (1.37–1.90)

1.44 (1.22–1.69)

1.10 (0.93–1.31)