Figure 3
A comparative venn diagram of significantly upregulated proteins (log2FC corresponding to q-value < 0.05) investigated by TMT quantitative proteomic approach for both female and male zebrafish liver following 10 µg/L fadrozole exposure for 21 days (see Supplementary excel table). Significantly upregulated female and male liver proteins are depicted in green and blue, respectively. The number of commonly regulated proteins is shown in red. (A) Upregulated proteins in the female liver were involved in fatty acid metabolism. (B) Metabolic process was the main upregulated signaling pathway in the male zebrafish liver. Statistically significant enrichment clustering of differentially expressed proteins were set at FDR of 5% and q ≤ 0.05.
