Figure 4
A comparative venn diagram of significantly downregulated proteins (log2FC corresponding to qvalue < 0.05) investigated by TMT quantitative proteomic approach for both the female and male zebrafish liver following 10 µg/L fadrozole exposure for 21 days. Significantly downregulated female and male liver proteins are depicted in green and blue, respectively. The number of commonly regulated proteins is shown in red. (A) Molecular functions downregulated in the female liver were vitellogenin (B), mTORC1 signaling (C), cellular response to estrogen stimulus (D) and esr1 transcription factor (E). Calcium signaling (F), mTORC1 signaling (G) and the esr1 transcription factor signaling (H) were the main downregulated pathways in the male zebrafish liver. Statistically significant pathway enrichment-based clustering of differentially expressed proteins were set at FDR of 5% and q ≤ 0.05.
