Figure 4
From: Reconstructed Skin Models Revealed Unexpected Differences in Epidermal African and Caucasian Skin
Regulation of proteins related to differentiation processes discriminates epidermis of African and Caucasian RS. Top 15 of differentially regulated proteins in epidermis from African and Caucasian in vitro RS. Experiments producing RS model with cells from donors A1 and C2 were performed in triplicate. Identified proteins from RS epidermis by at least 2 peptides or more in proteomic analyses were considered differentially produced with P ≤ 0.05 and |Fc| ≥ 1.2 and proteins were labelled in graph by the accession number and the official full name. Note that a part of the regulated proteins is related to the processing of filaggrin such as bleomycin hydrolase, histidine ammonia-lyase, arginase and caspase 14. # indicated regulations observed in the transcriptomic analysis in Fig. 2.
