Table 1 Classification of purified meningococcal OMP antigens based on their biological functions.

From: Immunogenicity profiling of protein antigens from capsular group B Neisseria meningitidis

 

Functiona

Total

Solubleb

Refolded

Foldedc

Unfolded

1

Adhesion

9

5

4

9

0

2

Redox homeostasis

6

6

0

5

1

3

Lysozyme inhibition

2

2

0

2

0

4

Peptidoglycan binding

2

2

0

2

0

5

OM assembly

6

2

4

6

0

6

Protein folding

7

7

0

7

0

7

Metabolism

3

3

0

2

1

8

Unknown function

4

2

2

3

1

9

Protein assembly

1

1

0

0

1

10

Peptidoglycan synthesis

4

3

1

4

0

11

Immunomodulation

4

1

3

4

0

12

OM stability

1

1

0

1

0

13

Macromolecular transport

17

5

12

14

3

14

Micromolecular transport

25

16

9

22

3

  

91

56

35

81

10

  1. aFunctional classification of selected proteins was carried out based on entries in the Pfam database75.
  2. bProteins were classified as soluble or refolded based on their solubility after initial cell disruption.
  3. cBased on thermal fluorescence denaturation profile.
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