Table 3 Multivariate relative risk of preterm birth according to biomarker levels by quartile in sample collected closest to delivery.

From: Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole

 

Quartile 1

Quartile 2

Quartile 3

Quartile 4

CHI3L1

1.00 (Reference)

1.21 (0.48, 3.12)

1.55 (0.62, 4.05)

1.49 (0.65, 3.59)

CRP

1.00 (Reference)

0.52 (0.22, 1.18)

0.69 (0.30, 1.52)

0.58 (0.22, 1.41)

IL-18BP

1.00 (Reference)

1.40 (0.59, 3.50)

1.18 (0.46, 3.10)

1.94 (0.65, 6.38)

IL-6a

1.00 (Reference)

—

—

—

sICAM-1

1.00 (Reference)

1.22 (0.45, 3.44)

1.49 (0.56, 4.01)

2.47 (1.01, 6.59)b

sTNFR2

1.00 (Reference)

1.26 (0.44, 3.72)

1.99 (0.83, 5.02)

3.30 (1.27, 10.00)c

  1. Relative risks and 95% confidence intervals were estimated using log-poisson models. Multivariate models adjusted for gravidity, sample gestational age, maternal age, BMI at enrollment. aQuartiles could not be generated based on the distribution of IL-6 concentration. bp = 0.05, cp = 0.02.
  2. Abbreviations: CHI3L1, chitinase-3-like 1; CRP, C-reactive protein; IL-6, interleukin 6; IL-18BP, interleukin 18 binding protein; sICAM-1, soluble intercellular adhesion molecule-1; sTNFR2, soluble tumor necrosis factor receptor 2.
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