Table 5 Analysis of Glaucoma Symptom Scale (GSS) and 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) scores by time, covariates and their interactions (multivariable model).

N = 150	P-valueBaseline QoL score*time	P-value Sex*time	P-value Age*time	P-value ^aStage*time	P-value BCVA*time	P-value Treat*time
Glaucoma Symptom Scale (GSS)
Symp-6	<0.001	0.673	0.594	0.113	0.950	0.619
Func-4	<0.001	0.256	0.759	0.009	0.333	0.940
GSS score	<0.001	0.561	0.855	0.108	0.984	0.921
National Eye Institute Visual Function Questionnaire (NEI-VFQ-25)
General health	0.001	0.345	0.248	0.759	0.186	0.239
General vision	<0.001	0.057	0.192	0.908	0.147	0.528
Ocular pain	<0.001	0.176	0.321	0.027	0.321	0.768
Near activities	<0.001	0.434	0.295	0.495	0.329	0.526
Distance activities^b	0.764	0.068	0.508	0.248	0.843	0.076
Social functioning^b	<0.001	0.907	0.690	0.172	0.760	0.054
Mental health	<0.001	0.262	0.643	0.269	0.701	0.203
Role difficulties^b	0.027	0.992	0.390	0.010	0.717	0.188
Dependency^b	0.024	0.425	0.544	0.127	0.459	0.927
Driving^c	0.069	0.565	0.518	0.706	0.391	0.906
Color vision^b	0.851	0.380	0.114	0.194	0.580	0.704
Peripheral vision^b	0.595	0.781	0.658	0.016	0.836	0.352
Total score	<0.001	0.188	0.344	0.548	0.834	0.541

Legend: N: Number of participants; BCVA: Best corrected visual acuity (≤0.15 LogMar, >0.15 LogMar); Treat: Number of drugs administered (>1 vs 1); ^aStage = Early (0/borderline/1), Moderate (2/3), Severe (4/5); ^bDichotomous scores (‘ = 100’, ‘<100’); ^cData available for 111 patients; Bold: Significant values.
Model: Score = Baseline score, time, Baseline score*time, time*gender, time*age, time*baseline stage, time*BCVA, time*Treat.

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