Figure 2
From: Tropomyosin-receptor kinase fused gene (TFG) regulates lipid production in human sebocytes
IGF-1 increases TFG levels. (a) SV-sebocytes were grown to 70–80% confluence and then received fresh medium without FBS and rhEGF. After an overnight incubation, cells were treated with the indicated concentrations of IGF-1 for 24 h. IGF-1 increased TFG levels in a dose-dependent manner (left panel). In a time-dependent experiment, SV-sebocytes were treated with 50 ng/ml of IGF-1 for the indicated times. IGF-1 increased TFG levels in a time-dependent manner (right panel). (b) Primary human sebocytes were treated with the indicated concentrations of IGF-1 for 24 h. IGF-1 increased the levels of TFG and lipogenic regulators in a dose-dependent manner.
