Figure 3 | Scientific Reports

Figure 3

From: High dose of dexamethasone protects against EAE-induced motor deficits but impairs learning/memory in C57BL/6 mice

Figure 3

Fingolimod but not dexamethasone protects against memory loss after EAE induction at the 8 dpi, on Recognition Novel Object Task. (A) No differences in discrimination ratio were found among groups at the 8 dpi, the training day. (B) EAE and EAE + DEX groups showed decreased memory consolidation 2 and 24 hours after training. (C) No differences were founded in discrimination ratio in all groups after Fingolimod (FTY-720) treatment, 8 dpi. (D) Treatment with FTY-720 protects against working memory impairment promoted by EAE 2 and 24 hour after training at 8 dpi. Results are shown as mean + SEM of the experimental groups. *p < 0.05 vs control; #p < 0.05 vs DEX or FTY-720. Two-way ANOVA test followed by the post-test Bonferroni, n = 6 to 12 for each group.

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