Figure 1 | Scientific Reports

Figure 1

From: Targeting GPER1 to suppress autophagy as a male-specific therapeutic strategy for iron-induced striatal injury

Figure 1

Sex differences in constitutive and inducible levels of GPER1 and ERα in the striatum. (a) GPER1. (b) ERα. Three microliters of ferrous citrate (FC) was infused into the right striatum. The constitutive and FC-induced levels of striatal GPER1 and ERα were compared between intact male and intact female mice. No sex difference in the level of constitutive GPER1, while FC-infusion increased the levels of GPER1 in males. The striatal protein level of ERα was lower in intact males than in intact females. The levels of both GPER1 and ERα were significantly increased by intrastriatal FC infusion in male mice but not in female mice. Data are expressed as the means ± s.e.m. (n = 6). *p < 0.05 compared with intact control male.

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