Figure 5 | Scientific Reports

Figure 5

From: Targeting GPER1 to suppress autophagy as a male-specific therapeutic strategy for iron-induced striatal injury

Figure 5

Silencing of ERα diminished the effects of E2 on FC-induced behavioral deficits, striatal injury, LC3 lipidation and lipid peroxidation in ovariectomized females but not in orchidectomized males. ERα siRNA was injected twice into the striatum at 1 day before and 5 h after FC infusion. (a) Forelimb-use asymmetry score. (b) Level of SBDP 145/150. (c) LC3 lipidation. (d) Level of 4-HNE. Data are expressed as the means ± s.e.m. (n = 6). **Indicates P < 0.01; *Indicates P < 0.05.

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