Figure 9
Radio-TLC analysis of the brain homogenates and blood samples obtained at 2, 30, and 60 min after injection of [18F]2 into ICR mice. [18F]2 (a); brain samples at 2 min (b), 30 min (c), and 60 min (d); blood samples at 2 min (f), 30 min (g), and 60 min (h). The 60-min samples (d and h) were further analyzed by radio-TLC using a 1:1:0.01 mixture of dichloromethane–methanol–triethylamine as the developing solvents (e and i). TLC analysis followed by fluorescence detection of the brain homogenates obtained at 2, 30, and 60 min after injection of 2 into Balb/C nude mice (j). The sample was spotted 1 cm from the bottom and the solvent front moved 7 cm from the bottom using a 4:1 mixture of ethyl acetate–hexane.
