Figure 2 | Scientific Reports

Figure 2

From: Estrogen-related receptor alpha induces epithelial-mesenchymal transition through cancer-stromal interactions in endometrial cancer

Figure 2

Effects of ERRα on EMT markers and motility of cancer cells through cancer-stromal interactions. The expression of vimentin, Snail, and ZEB1 in Ishikawa (A) and HEC-1A (B) cells co-cultured with T-HESCs, after overexpression of ERRα/PGC-1α, was examined by qPCR. The wound healing assays of Ishikawa (C) and HEC-1A (D) cells co-cultured with T-HESCs, after knockdown of ERRα (n = 3). The expression of vimentin, Snail, and ZEB1 in Ishikawa (E) and HEC-1A (F) cells co-cultured with T-HESCs, after ERRα knockdown, was examined by qPCR. Data represent the mean ± standard error of the mean. P values are based on Student’s t-test and one-way ANOVA with post-hoc Tukey’s multiple comparison test. *P < 0.05; **P < 0.01.

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