Table 1 Association analysis results for the top 15 SNPs in the discovery cohort.
SNP | Chr | Location | Risk allele | Freq in cases | Freq in control | P-value | Odds ratio | OR – 95% CI | OR + 95% CI |
|---|---|---|---|---|---|---|---|---|---|
rs12476782 | 2 | 191472880 | A | 0.26 | 0.16 | 2.38 × 10−4 | 1.9 | 1.4 | 2.6 |
rs11625840 | 14 | 22627848 | A | 0.38 | 0.26 | 2.66 × 10−4 | 1.7 | 1.3 | 2.3 |
rs2242543 | 14 | 22694331 | A | 0.36 | 0.25 | 3.77 × 10−4 | 1.7 | 1.3 | 2.4 |
rs79840975 | 18 | 56209387 | T | 0.02 | 0.08 | 4.06 × 10−4 | 0.3 | 0.1 | 0.5 |
rs11585994 | 1 | 8258226 | C | 0.16 | 0.26 | 4.18 × 10−4 | 0.5 | 0.4 | 0.8 |
rs988997 | 14 | 22693832 | G | 0.36 | 0.25 | 4.57 × 10−4 | 1.7 | 1.3 | 2.3 |
rs10488042 | 7 | 101652458 | A | 0.19 | 0.11 | 4.87 × 10−4 | 2.1 | 1.4 | 3.1 |
rs7130129 | 11 | 65354926 | A | 0.42 | 0.54 | 5.27 × 10−4 | 0.6 | 0.5 | 0.8 |
rs2240985 | 2 | 37899654 | A | 0.08 | 0.16 | 8.07 × 10−4 | 0.5 | 0.3 | 0.7 |
rs11228991 | 11 | 57078876 | G | 0.12 | 0.06 | 8.76 × 10−4 | 2.4 | 1.4 | 3.9 |
rs12717364 | 14 | 22693912 | C | 0.50 | 0.38 | 9.86 × 10−4 | 1.6 | 1.2 | 2.0 |
rs13379037 | 14 | 22693679 | C | 0.50 | 0.38 | 1.03 × 10−3 | 1.6 | 1.2 | 2.0 |
rs2595370 | 18 | 29239527 | A | 0.09 | 0.16 | 1.09 × 10−3 | 0.5 | 0.3 | 0.7 |
rs2468842 | 11 | 18154120 | A | 0.16 | 0.26 | 1.12 × 10−3 | 0.6 | 0.4 | 0.8 |
rs4823231 | 22 | 46088119 | T | 0.16 | 0.25 | 1.12 × 10−3 | 0.6 | 0.4 | 0.8 |
