Table 2 Association results for the top validated SNPs.
SNP | rs4823231 | rs11913168 | rs72710816 | rs79840975 | rs17428132 | rs1877782 | |
|---|---|---|---|---|---|---|---|
Chromosome | 22 | 22 | 5 | 18 | 6 | 15 | |
location (base pair) | 46088119 | 30606564 | 97562 | 56209387 | 32687119 | 90703836 | |
risk allele | T | A | C | T | T | A | |
Validation method | Sequenom | GWAS array | Sequenom | Sequenom | Sequenom | Sequenom | |
Meta-analysis | P-value | 9.58 × 10−5 | 3.46 × 10−3 | 0.014 | 0.031 | 0.032 | 0.047 |
Odds ratio | 0.7 | 0.8 | 1.3 | 0.6 | 0.8 | 0.8 | |
Discovery – Western Europe | P-value | 1.12 × 10−3 | 8.69 × 10−3 | 2.99 × 10−3 | 4.06 × 10−4 | 2.52 × 10−3 | 1.40 × 10−3 |
Frequency in cases | 0.16 | 0.07 | 0.14 | 0.02 | 0.34 | 0.20 | |
Frequency in controls | 0.25 | 0.13 | 0.08 | 0.08 | 0.46 | 0.29 | |
Odds ratio | 0.6 | 0.5 | 2.0 | 0.3 | 0.7 | 0.6 | |
Validation – Western Europe | P-value | 0.10 | 0.21 | 0.56 | 0.20 | 0.49 | 0.48 |
Frequency in cases | 0.13 | 0.10 | 0.11 | 0.04 | 0.41 | 0.25 | |
Frequency in controls | 0.17 | 0.12 | 0.10 | 0.06 | 0.47 | 0.27 | |
Odds ratio | 0.7 | 0.8 | 1.1 | 0.7 | 0.8 | 0.9 | |
Validation - Spain | P-value | 0.18 | 0.53 | 0.24 | 0.93 | 0.75 | 1.00 |
Frequency in cases | 0.14 | 0.09 | 0.14 | 0.03 | 0.40 | 0.23 | |
Frequency in controls | 0.16 | 0.10 | 0.12 | 0.03 | 0.40 | 0.23 | |
Odds ratio | 0.8 | 0.9 | 1.2 | 1.0 | 1.0 | 1.0 | |
Validation - UK | P-value | 0.12 | 0.037 | 0.25 | 0.12 | 0.68 | 0.030 |
Frequency in cases | 0.15 | 0.09 | 0.13 | 0.03 | 0.37 | 0.23 | |
Frequency in controls | 0.19 | 0.11 | 0.11 | 0.05 | 0.38 | 0.29 | |
Odds ratio | 0.8 | 0.8 | 1.3 | 0.6 | 0.9 | 0.7 | |
