Figure 3 | Scientific Reports

Figure 3

From: Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology

Figure 3

Contraction of control and AAA patient’ SMC upon ionomycin stimulation. (a) Representative resistance curves generated by control 1 (black) and patient 1 (grey) SMC before and after stimulation of contraction. Resistance values were measured in duplicate and represented as mean with SD. Vertical dotted line marks the stimulation with ionomycin. (b) Mean contractile response of control (▲; n = 6) and AAA patient (■; n = 21) SMC upon ionomycin stimulation derived from multiple experiments. (c) Maximum contractile response of control (▲; n = 6) and AAA patients’ (■; n = 21) SMC upon ionomycin stimulation. (d) Mean contractile response of control (▲; n = 6), non-ruptured AAA patients’ (⊠; n = 13) and ruptured AAA patients’ (□; n = 7) SMC from multiple experiments. (e) Maximum contractile response of control (▲; n = 6), non-ruptured AAA patients’ (⊠; n = 13) and ruptured AAA patients’ (□; n = 7) SMC. Contraction is expressed in percentages of decrease compared to baseline value. Boxplots are shown as median with range.

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