Figure 3
PLC-β3 and p63RhoGEF bind Gαq with a structurally-similar helix-turn-helix motif. (a) The structure of Gαq–p63RhoGEF (PDB ID: 2RGN). p63RhoGEF is shown as a ribbon diagram, with its Dbl homology (DH) domain colored turquoise, its Pleckstrin homology (PH) domain colored dark blue, and its helix-turn-helix motif (residues 468–490) colored light blue. (b) The structure of Gαq–PLC-β3 (PDB ID: 3OHM). PLC-β3 is shown as a magenta ribbon diagram, except for the PH domain that is colored purple. The PLC-β3 helix-turn-helix motif (residues 852–874) is colored blue. (c) Superimposition of the complexes of Gαq with PLC-β3 and p63RhoGEF, using only the coordinates of Gαq for the superimposition. p63RhoGEF is colored turquoise and PLC-β3 is colored magenta, with the helix-turn-helix motifs colored light blue and blue, as in panels a and b, respectively. Gαq in all panels is shown as in Fig. 1b.
