Figure 1
From: Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver
Long-term follow-up of total cholesterol levels. Total cholesterol values were analyzed monthly for the 1-year follow-up after intraportal gene transfer of lenti- and AAV vectors. (a) Lenti-LDLR (n = 6) gene transfer led to a significant decrease in total cholesterol compared to lenti-control (n = 4). (b) AAV9-LDLR (n = 11) was not significantly more efficient than AAV9-control (n = 6) in lowering serum cholesterol although a trend was seen during the first 6 months whereas AAV2-LDLR gene transfer (n = 5) failed to show a treatment effect at any time point compared to AAV2-control (n = 7) (c). Data are expressed as percentage (mean ± SEM) change in comparison to the pre-treatment values in each treated animal. Statistical significance was evaluated using Linear Mixed Models analysis (R statistical software, version 3.2.5). P < 0.05 was considered statistically significant.
