Figure 3
From: Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver
Histological characterization of AAV-control and AAV-LDLR transduced rabbit livers. Representative images of hematoxylin-eosin stained liver sections 1 and 12 months after liver-directed gene transfers. One month after gene transfer ballooning degeneration, microvesicular and macrovesicular steatosis were seen in all AAV-transduced animals (a,c,e,g). Widespread bile duct proliferation was seen in AAV2-LDLR transduced animals 12 months after gene transfer (b,i–l). Magnification 200x, inserts 400x (a–h). Scale bar: 100 µm. Composite images comprising four 40x images are shown in (i–l) from four different liver lobes from AAV2-LDLR transduced rabbit. Arrowheads indicate generalized pathological findings.
