Figure 2 | Scientific Reports

Figure 2

From: The selective disruption of presynaptic JNK2/STX1a interaction reduces NMDA receptor-dependent glutamate release

Figure 2

(A) The amino acid sequence corresponding to the region of contact between JNK and STX1a has been aligned for all 3 JNK isoforms. It emerged that in that region JNK2 has several specific amino acids while JNK1 and JNK3 are mostly equal. Red box represent the sequence area that is bind by the N-terminal sequence of STX1a. (B) 3D structure of the molecular docking resolving the possible interaction between JNK2 (Grey) and the N-terminal portion of STX1a (Red) (1). The image originates from a computational analysis that allowed the determination of the ‘minimal contact area’ between the two proteins (2). (C) Figurative cartoon that summarizes the peptide forms that have been synthesized and used for the experiments.

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