Table 2 Correlations identified between levels of cytokines in tear fluid and clinical ocular parameters.

From: Elevated cytokine levels in tears and saliva of patients with primary Sjögren’s syndrome correlate with clinical ocular and oral manifestations

Clinical Parameters

 

IL_1ra

IL_2

IL_4

IL_8

IL_12p70

IL_17A

IFN_y

MIP_1b

Rantes

Age

r

   

0.261*

     

Osmolarity

r

0.389*

0.265*

0.274*

0.454**

  

0.354*

0.421*

0.406*

TFBUT

r

−0.388*

 

−0.349*

−0.340*

−0.280*

 

−0.362*

−0.315*

−0.405*

Schirmer I

r

−0.629**

−0.463**

−0.579**

−0.494**

−0.459**

−0.462**

−0.629**

−0.626**

−0.727**

OSS

r

0.443**

0.359*

0.380*

0.440**

0.333*

0.315*

0.445**

0.560**

0.533**

CS

r

0.313*

 

0.310*

0.481**

0.264*

 

0.360*

0.538**

0.522**

DESL

r

0.513**

0.392*

0.490**

0.474**

0.414*

0.380*

0.546**

0.550**

0.637**

  1. TFBUT: tear film breakup time; OSS: ocular surface staining; CS: corneal staining; DESL: dry eye severity level. Correlation coefficient r was tested with Spearman correlation test, statistical significant is set at *p < 0.05 level and **p < 0.001.
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