Figure 2

Association between miRNAs of interest and their predicted targets in the insulin signaling pathway (A) and Type II diabetes mellitus pathway (B)⁵². Transcripts whose expression correlated significantly (p < 0.05) with the miRNAs of interest and whose levels were independently and significantly associated with the targeting miRNA in the fully adjusted regression model* are marked with grey boxes. MicroRNAs whose expression correlated positively with glucose/insulin/HbA1c are indicated in red, while those with a negative correlation or down-regulation in individuals with IFG in comparison to NG are indicated in blue. Positive correlation between miRNA and its target mRNA is marked with and negative correlation with . *Statistical model: Stepwise AIC linear regression model including the miRNA of interest, age, sex, BMI, leukocyte count, erythrocyte count, thrombocyte count, glycemic status, glucose insulin, as well as HbA1c levels, HbA1c%, and HOMA2 IR index statistically predicting the mRNA target.