Table 3 Significant (pc < 0.05) associations between miRNAs and serum glucose and insulin levels, the HOMA2 insulin resistance index, and glycated hemoglobin (HbA1c) levels and percentage in normoglycemic individuals and prediabetics separately.

From: Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes

 

Serum glucose

Insulin

HOMA2-IR

HbA1c

HbA1c %

p-value

r/β

p-value

r/β

p-value

r/β

p-value

r/β

p-value

r/β

In normoglycemic individuals

hsa-miR-589-3p

Correlation

  

0.007

−0.117

0.007

−0.117

1.80*10−5

−0.185

4.80*10−5

−0.175

Model 1

  

0.045

−0.077

0.049

−0.075

4.61*10−5

−0.167

1.37*10−4

−0.154

Model 2

      

1.03*10−4

−0.158

2.68*10−4

−0.147

hsa-miR-221-3p

Correlation

      

4.50*10−5

0.176

1.29*10−4

0.165

Model 1

      

4.05*10−6

0.189

7.57*10−6

0.181

Model 2

      

7.47*10−5

0.170

1.15*10−4

0.163

hsa-miR-642a-5p

Correlation

      

7.80*10−5

0.170

2.63*10−4

0.157

Model 1

      

7.20*10−6

0.184

1.91*10−5

0.173

Model 2

      

2.49*10−6

0.192

5.58*10−6

0.183

hsa-miR-454-5p

Correlation

      

2.42*10−4

−0.174

1.34*10−4

−0.181

Model 1

      

1.54*10−4

−0.170

9.94*10−5

−0.171

Model 2

      

2.23*10−4

−0.165

1.40*10−4

−0.167

In individuals with IFG

hsa-miR-885-5p

Correlation

9.00*10−5

0.244

0.038

0.131

0.029

0.138

    

Model 1

0.007

0.169

0.010

0.135

0.007

0.142

    

Model 2

0.008

0.167

0.007

0.141

0.005

0.146

    

hsa-miR-106b-5p

Correlation

9.20*10−5

0.244

0.048

0.124

0.036

0.132

    

Model 1

2.82*10−4

0.223

    

0.041

−0.127

0.043

−0.125

Model 2

2.09*10−4

0.230

        

hsa-miR-122-5p

Correlation

  

8.42*10−7

0.334

9.31*10−7

0.333

    

Model 1

  

2.81*10−4

0.206

3.00*10−4

0.206

    

Model 2

  

1.76*10−4

0.207

2.05*10−4

0.206

    

hsa-miR-146b-5p

Correlation

      

4.90*10−5

0.254

6.30*10−5

0.250

Model 1

      

2.56*10−5

0.260

4.41*10−5

0.252

Model 2

      

6.05*10−5

0.251

5.25*10−5

0.252

  1. Associations are evaluated with Spearman’s correlation and stepwise regression models. *Multiply sign. Only p-values smaller than 0.05 are shown here, and those with a pc < 0.05 are indicated by bold font. All p-values, numbers of samples, and 95%CIs are shown in Supplementary Tables 4 and 5.
  2. Statistical model: Correlation = Spearman’s correlation; Model 1 = Stepwise regression model including miRNA of interest (one by one), age, sex, and BMI; Model 2 = Model 1 + leukocyte, erythrocyte, and thrombocyte count, in addition to total cholesterol, LDL, HDL, and triglyceride levels, as well as glycemic status, alcohol consumption, and history of smoking or hypertension.
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