Table 4 Pathways enriched with the predicted targets of the miRNAs of interest.
Description | Genes in pathway | Genes in overlap | p-value | FDR q-value |
|---|---|---|---|---|
Hsa-miR-221-3p | ||||
Insulin signaling pathway | 137 | 8 | 6.60*10−5 | 0.006 |
Type II diabetes mellitus | 47 | 5 | 9.63*10−5 | 0.006 |
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | 25 | 4 | 9.75*10−5 | 0.006 |
Alzheimer’s disease | 169 | 8 | 2.81*10–4 | 0.012 |
Cysteine and methionine metabolism | 34 | 4 | 3.33*10−4 | 0.012 |
Tight junction | 134 | 7 | 3.72*10−4 | 0.012 |
Purine metabolism | 159 | 7 | 0.001 | 0.027 |
Spliceosome | 128 | 6 | 0.002 | 0.039 |
Hsa-miR-146b-5p | ||||
Toll-like receptor signaling pathway | 102 | 6 | 1.04*10−4 | 0.017 |
Adherens junction | 75 | 5 | 2.21*10−4 | 0.017 |
Peroxisome | 78 | 5 | 2.65*10−4 | 0.017 |
Regulation of actin cytoskeleton | 216 | 7 | 0.001 | 0.045 |
Epithelial cell signaling in Helicobacter pylori infection | 68 | 4 | 0.002 | 0.045 |
Pancreatic cancer | 70 | 4 | 0.002 | 0.045 |
Leishmania infection | 72 | 4 | 0.002 | 0.045 |
Lysosome | 121 | 5 | 0.002 | 0.045 |
Endocytosis | 183 | 6 | 0.002 | 0.046 |
Spliceosome | 128 | 5 | 0.002 | 0.046 |
