Figure 1 | Scientific Reports

Figure 1

From: Th1, Th17, and Treg Responses are Differently Modulated by TNF-α Inhibitors and Methotrexate in Psoriasis Patients

Figure 1

Analysis of cytokines in culture supernatant of PBMC, incubated for 48 h in the presence of medium (unstimulated) or with anti-CD3 and anti-CD28 mAbs (stimulated). The PBMCs were obtained prior to pulse therapy (day 0) and during pulse therapy (day 7) of patients with severe plaque psoriasis treated with anti-TNF agents. (A) IL-17 levels (*Wilcoxon; p < 0.05), (B) IFN-γ levels (*Wilcoxon; p < 0.05), (C) TNF-α levels (Wilcoxon; p > 0.05), (D) IL-10 levels (*Wilcoxon; p < 0.05), (E) IL-6 levels (*Wilcoxon; p < 0.05). The results are expressed in pg/mL. *Indicates statistical significance.

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