Figure 3 | Scientific Reports

Figure 3

From: Th1, Th17, and Treg Responses are Differently Modulated by TNF-α Inhibitors and Methotrexate in Psoriasis Patients

Figure 3

Analysis of cytokines in culture supernatant of PBMC, incubated for 48 h in the presence of medium (unstimulated) or with anti-CD3 and anti-CD28 mAbs (stimulated). The PBMCs were obtained from healthy subjects (Ctrl), psoriasis patients without therapy (WT), patients treated with methotrexate (MTX), and patients treated with immunobiologicals (IB). Panel A: IFN-γ levels (aWilcoxon; p < 0.05), panel B: IL-17 levels (aWilcoxon p < 0.05), panel C: TNF-α levels (aWilcoxon; p < 0.05 and *Kruskal-Wallis p < 0,05), panel D: IL-10 levels (aWilcoxon p < 0.05 and *Kruskal-Wallis p < 0,05), panel E: IL-6 levels (aWilcoxon; p = 0.05 and *Kruskal-Wallis p < 0,05). The results are expressed in pg/mL. a and *indicate statistical significance.

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