Figure 3
X-ray structure of PTPN3-PDZNext bound to HPV16E6 PBM. (A) Sequence and secondary-structure elements in PTPN3-PDZNext. No electron density was observed for the residues shown in gray. (B) Left panel: Overall structure of PTPN3-PDZNext bound to HPV16E6 PBM displayed as a ribbon. The structure is colored according to secondary structure elements (β-strands in blue, helices in red, and loops in white). The peptide (in yellow) enters the PDZ-binding pocket delimited by the β2 strand, the α2 helix, and the “GLGF” loop 519GKFGF523. Right panel: Detailed view of the PTPN3-PDZ bound to HPV16E6 PBM. Important residues are shown as sticks in CPK colors, molecules of water are represented as red spheres, and intermolecular H-bonds and polar contacts are shown as black dashed lines.
