Figure 3 | Scientific Reports

Figure 3

From: Nicotinamide phosphoribosyltransferase is a molecular target of potent anticancer agents identified from phenotype-based drug screening

Figure 3

NAMPT gene mutation in K542 cell lines with acquired resistance. (a,b) Cell viability curves of K542-resistant HT-1080 (HT-1080-R) and its parent cell line (a) and K542-resistant DLD-1 (DLD-1-R2) and its parent cell line (b) in the presence of K542 or Taxol. Data indicate the mean ± s.e.m., n = 3. (c) A radar chart showing the IC50 value (nM) of K542 and some anticancer drugs against K542-resistant cells and their parent cells. (d) The nucleotide sequence of NAMPT cDNA of K542-resistant cells and their parent cells. The nucleotide symbol “M” is A or C and “Y” is C or T.

Back to article page