Table 1 Structure-activity relationship and affinity probe synthesis of benzofuran analog.
Compound | R2 | R7 | R2′ | R6′ | RMG-I GI50 (nM) | ES-2 GI50 (nM) |
|---|---|---|---|---|---|---|
| ||||||
K405 |
|
|
|
| 20 | >1000 |
K142 |
|
|
|
| 24 | >1000 |
K143 |
|
|
|
| 16.9 | >1000 |
K391 |
|
|
|
| >1000 | >1000 |
K393 |
|
|
|
| 0.8 | >1000 |
K141 |
|
|
|
| >1000 | >1000 |
K710 |
|
|
|
| 690 | >1000 |
K150 |
|
|
|
| 7.4 | >1000 |
K461 |
|
|
|
| 120 | >1000 |
Bnz-tag |
|
|
|
| N.T.a | N.T.a |
