Table 2 Structure-activity relationship and affinity probe synthesis of indole analog.

From: Nicotinamide phosphoribosyltransferase is a molecular target of potent anticancer agents identified from phenotype-based drug screening

Compound

R1

R2

R5′

RMG-I GI50 (nM)

ES-2 GI50 (nM)

K542

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1.8

>1000

K543

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82

>1000

K541

0.7

>1000

K216

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<1

>1000

K270

>300

>1000

K336

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>1000

>1000

K209

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6.1

>1000

Ind-tag

N.T.a

N.T.a

  1. aNot Tested.
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