Table 4 IC50 values and IC50 ratio of K542-resistant HT-1080 and DLD-1 cell lines.

From: Nicotinamide phosphoribosyltransferase is a molecular target of potent anticancer agents identified from phenotype-based drug screening

Compound

HT-1080

DLD-1

WTe IC50 (nM)

R IC50 (nM)

Ratiof

WTe IC50 (nM)

R2 IC50 (nM)

Ratiof

K542

31

1200

39

120

1900

16

ADMa

4.8

5.9

1.2

380

360

0.95

TXLb

3.0

4.9

1.6

150

150

1.0

GEMc

3.3

3.1

0.93

30

22

0.74

BTZd

14

21

1.5

10

19

1.0

  1. aAdriamycin.
  2. bTaxol.
  3. cGemcitabine.
  4. dBortezomib.
  5. eParent cells of each cell lines.
  6. fRatio of Resistant IC50/Parent IC50.
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