Table 2 Earlier reported mutations but substituted with different amino acids at the same positions therefore considered as novel mutations in HIV-1 seronegative individuals.

From: Genetic Polymorphisms in the Open Reading Frame of the CCR5 gene From HIV-1 Seronegative and Seropositive Individuals From National Capital Regions of India

Sample Codes

Variations in Nucleotide

Variations in Amino acid

Nature of Variations

Allelic Frequency

Also observed in other Population

—

A34C

I12L

—

—

Caucasians

V59

A34G*

I12V*

C

(1/70)

NCRs of India

—

T58A

C20S

—

—

Caucasians

V6

T58C*

C20R*

NC

(2/70)

NCRs of India

—

T164A

L55Q

—

—

Caucasians

V82, V100

T164C*

L55P*

C

(4/70)

NCRs of India

—

G180T

R60S

—

—

African Americans

V112

G179A*

R60K*

C

(1/70)

NCRs of India

V150

A178G*

R60G*

NC

(1/70)

NCRs of India

—

T303A

C101X

—

—

African Americans

V6

G302A*

C101Y*

NC

(2/70)

NCRs of India

—

Δ352–354

Δ118F

—

—

Nepalese

V24

T352C*

F118L*

C

(1/70)

NCRs of India

V108

T353C*

F118S*

NC

(1/70)

NCRs of India

—

G459T

W153C

—

—

Southern Chinese

V30

G458T*

W153L*

C

(3/70)

NCRs of India

—

T644C

S215L

—

—

African Americans

S115

T643C*

S215P*

NC

(1/70)

NCRs of India

—

C673T

R225X

—

—

Africans

—

G674A

R225Q

—

—

Africans

S120

G674C*

R225P*

NC

(1/70)

NCRs of India

—

G990A

E330E

—

—

Not known

V13

G988A*

E330K*

C

(3/70)

NCRs of India

—

G1007T

S336I

—

—

Southern Chinese

V122

A1006G*

S336G*

NC

(1/70)

NCRs of India

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