Table 1 Patient’s demographic, tumour and treatment characteristics.

From: Establishment and genomic characterization of gingivobuccal carcinoma cell lines with smokeless tobacco associated genetic alterations and oncogenic PIK3CA mutation

 

ITOC-01

ITOC-02

ITOC-03

ITOC-04

Patient age, Gender & Ethnicity

28 years, Male, Indian

43 years, Female, Indian

37 years, Male, Indian

61 years, Male, Indian

Primary site

Buccal mucosa

Oral tongue

Buccal mucosa

Buccal mucosa

Histology (grade)

SCC (poorly differentiated)

SCC (poorly differentiated)

SCC (moderately differentiated)

SCC (poorly differentiated)

Pathological staging

T4N2cM0

T4aN0

T3N2bM0

T4aN2bM0

Habits

Chronic tobacco chewer using Gutka, Masheri, Paan with tobacco & Snuff. No smoking or alcohol.

Chronic tobacco chewer using Masheri. No smoking or alcohol.

Chronic tobacco chewer. No smoking or alcohol.

Chronic tobacco chewer using Gutka. No smoking or alcohol.

Treatment details

Radical surgery followed by radiotherapy (RT) + chemotherapy (CT)

Radical surgery followed by RT + CT

Radical surgery followed by RT + CT

Neoadjuvant Paclitaxel and Carboplatin chemotherapy followed by radical surgery. Subsequent adjuvant RT + CT

Treatment outcome

Rapid progression and died after 6 months

Rapid progression after 6 months of treatment

Disease controlled at 1 year follow up

Disease controlled at 6 month follow up

  1. Masheri: Burnt tobacco applied over gums; Paan: Betel leaves with lime, catechu and areca nut.