Table 1 Impact of 100,000 platelets/µl vs. 10,000 platelets/µl on thrombin generation parameters of all studied cord blood derived samples (n = 10) and adult samples (n = 10) without rFVIIa.

From: Neonatal thrombocytopenia: Thrombin generation in presence of reduced platelet counts and effects of rFVIIa in cord blood

cord blood

100,000/μl

10,000/μl

lag time [min]

3.4 (±0.46)§§

3.5 (±0.60)§§

ETP [nMol × min]

1238.7 (±176.3)§§

1225.4 (±144.2)§§

peak [nMol]

168.1 (±27.8)§

168.9 (±27.3)§§

time-to-peak [min]

6.9 (±0.64)§§

7.1 (±0.74)§§

velix [nMol/min]

48.9 (±11.9)§§

49.0 (±14.1)§§

adult blood

lag time [min]

4.6 (±0.56)

4.6 (±0.48)

ETP [nMol × min]

2106.3 (±208.1)

1860.3 (±144.6)**

peak [nMol]

144.7 (±27.6)

100.4 (±38.8)**

time-to-peak [min]

13.5 (±3.34)

11.7 (±2.69)

velix [nMol/min]

19.6.4 (±12.0)

17.3 (±11.1)

  1. **Marks a significant difference between the two platelet counts (**p < 0.001). §Marks a significant difference between adult and cord blood samples at the same platelet count (§p < 0.05; §§p < 0.001). ETP (endogenous thrombin potential), velix (velocity index).
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