Table 2 Relative impact of decreasing platelet counts on all parameters of thrombin generation with 1.5 µg/ml rFVIIa vs. vehicle.

cord blood	lag time [min]	ETP	peak	ttpeak	velix
cord blood	lag time [min]	[nMol × min]	[nMol]	[min]	[nMol/min]
100,000/µl	0.62 ± 0.02**^§	0.96 ± 0.13	0.94 ± 0.04*	0.84 ± 0.03*^§	0.87 ± 0.04*§
75,000/µl	0.65 ± 0.03*^§§	0.93 ± 0.17	0.92 ± 0.05*	0.87 ± 0.05*^§	0.85 ± 0.07*§
50,000/µl	0.65 ± 0.02**^§	0.95 ± 0.12	0.91 ± 0.05*	0.86 ± 0.01**^§	0.85 ± 0.07*
10,000/µl	0.66 ± 0.07*^§	0.98 ± 0.02	0.93 ± 0.03*	0.87 ± 0.03*^§	0.86 ± 0.10
PPP	0.64 ± 0.05*^§	0.95 ± 0.10	0.91 ± 0.04*^§	0.86 ± 0.03*^§	0.82 ± 0.08*
*adult blood*
100,000/µl	0.75 ± 0.06**	0.99 ± 0.03	0.98 ± 0.05	0.90 ± 0.04*	0.99 ± 0.09
75,000/µl	0.80 ± 0.03**	1.01 ± 0.06	0.99 ± 0.06	0.94 ± 0.03*	0.98 ± 0.08
50,000/µl	0.77 ± 0.05**	0.97 ± 0.03	0.95 ± 0.03	0.97 ± 0.08	0.89 ± 0.10
10,000/µl	0.76 ± 0.06*	0.98 ± 0.09	0.99 ± 0.07	0.93 ± 0.05*	0.94 ± 0.07
PPP	0.77 ± 0.03**	0.97 ± 0.05	0.96 ± 0.04	0.94 ± 0.04*	0.89 ± 0.08

Ratios for each parameter were formed from absolute values with/without rFVIIa. Samples from cord blood derived and adult plasma with platelet counts of 100,000/µl, 75,000/µl, 50,000/µl, 10,000/µl and platelet poor plasma (PPP) with rFVIIa at 1.5 µg/ml (n = 5). *Marks a significant difference to baseline level of the same platelet count (*p < 0.05; **p < 0.001). ^§Marks a significant difference between adult and cord blood samples (^§p < 0.05; ^§§p < 0.001). ETP (endogenous thrombin potential), ttpeak (time-to-peak), velix (velocity index).

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