Figure 1
From: Cynomolgus macaque IL37 polymorphism and control of SIV infection
The polymorphic positions (1), (2), (3) and (4) correspond to positions 17064328, 17064347, 17064414, and 17064452 of Mafa chr.13 (whole genome annotation v5.0), respectively. The SNP at position (4) (Chr.13 :17064452) was significantly associated to the SP-PVL. Mafa-ref correspond to the sequence of the Macaca_fascicularis_5.0 genome annotation. Arrow 1. The macaque exon 1 displays an in-frame ATG codon nine codon upstream of the ATG start codon of the human IL-37 gene. In the human genome, this start codon is absent. Arrow 2. Location of the human IL-37 start codon. Arrow 3. A 27 bp motif is duplicated in the most frequent IL-37 macaque alleles studied here. This insertion was absent in one allele of animal 10465_IL1F7. A similar allele was found in another animal (animal 8102) among the 44 Mauritian cynomolgus macaques studied here (see text for details). Arrow 4. The 27 bp repeat is absent from Mafa and Mamu whole genome annotations. It is also absent from the human IL-37 gene. The 3′ duplicated 27 bp motif differs from its homologue by one base (there is a T at position 207 instead of a C at position 180). This substitution is synonymous.
