Table 3 Genotypes of the three NS-SNPs with 22 animals above the median log-PVL and 22 animals below the median log-PVL.

From: Cynomolgus macaque IL37 polymorphism and control of SIV infection

Locus name

CD244

IRF9

IL37 (IL37)

Chromosome

Chr.1

Chr.7

Chr.13

Location

90,806,827

87,945,244

17,064,452

Ref./Var.

C/T

A/G

C/T

Odds Ratio

4.59

1.34

19.52

95% confidence

1.27 to 21.09

0.51 to 3.57

2.70 to 863.87

p

0.016

0.656

3.33 × 10 −4

Animals (route) [log-PVL]

23037 (IR) [0.000]

C/C

A/A

C/C

14468 (IR) [1.732]

C/C

A/A

C/C

9204 (IV) [1.778]

C/C

A/A

C/C

11137 (IV) [1.778]

C/C

A/A

C/C

11245 (IV) [1.778]

C/C

A/A

C/C

11637 (IV) [1.778]

C/T

G/G

C/C

15885 (IR) [1.959]

C/T

A/A

C/C

OBHJ6 (IR) [2.153]

C/C

A/A

C/C

9413 (IV) [2.222]

C/C

G/G

C/T

OBG7 (IR) [2.228]

C/C

A/A

C/C

OBPR6 (IR) [2.283]

C/C

A/A

C/C

Z776 (IV) [2.477]

C/C

G/G

C/C

10515 (IV) [2.526]

C/C

A/G

C/C

10228 (IV) [2.565]

C/C

G/G

C/C

15461 (IR) [2.613]

C/C

A/A

C/C

11296 (IV) [2.771]

C/C

A/G

C/C

OBFE6 (IR) [2.899]

C/C

A/G

C/C

9691 (IV) [2.905]

C/C

A/A

C/C

20595 (IV) [2.964]

C/C

A/A

C/C

8249 (IV) [2.998]

C/C

A/A

C/C

23060 (IR) [3.094]

C/T

A/G

C/C

20351 (IR) [3.094]

C/T

G/G

C/C

20654 (IV) [3.137]

C/C

A/A

C/C

15232 (IR) [3.273]

T/T

A/G

C/T

10116 (IV) [3.398]

C/C

A/A

C/C

15693 (IV) [3.428]

C/C

A/A

C/T

473 (IV) [3.499]

T/T

A/G

C/C

10024 (IV) [3.544]

C/T

A/A

C/C

9345 (IV) [3.614]

C/C

A/A

C/C

20525 (IV) [3.925]

C/C

A/G

C/T

9859 (IV) [4.004]

C/C

A/A

C/T

8141 (IV) [4.053]

C/C

A/G

C/C

15596 (IV) [4.053]

C/T

A/A

C/T

23014 (IR) [4.124]

C/C

A/A

C/T

OBRG6 (IR) [4.262]

C/C

A/G

C/C

4763 (IV) [4.326]

C/C

G/G

C/C

8102 (IV) [4.506]

C/C

G/G

T/T

20483 (IV) [4.586]

C/C

A/G

C/T

11360 (IV) [4.828]

T/T

G/G

C/C

Z860 (IV) [4.968]

C/T

A/A

T/T

Z857 (IV) [5.239]

C/T

G/G

C/T

OBRF6 (IR) [5.265]

T/T

A/A

C/C

10435 (IV) [5.399]

C/T

G/G

C/T

10465 (IV) [5.559]

C/T

A/G

C/T

  1. The odds ratio and 95% confidence interval (CI) were calculated as detailed in Materials and Methods. Probabilities of association (p) were obtained using the Fisher exact test. Significant p values are represented in bold.
  2. We tested the effect of these three gene variants on the PVL using a linear model. We also introduced information on the MHC haplotypes, since these haplotypes were previously shown to influence PVL. The seven haplotypes described in this population were treated as binary variables (presence or absence). Starting from the full model, we removed the non-significant terms in a stepwise manner. This left only three significant predictors, namely IL37 SNP (p = 0.0026), M2 (p = 0.0027), and M6 (p = 0.0023) haplotypes. These three factors in conjunction explained 48% of the PVL variance (p = 4.8 × 10−6).