Table 1 Comparison of clinical characteristics, laboratory parameters, clinical outcomes and scoring systems between subgroups in AP patients.

From: Serum apolipoprotein B-to-apolipoprotein A1 ratio is independently associated with disease severity in patients with acute pancreatitis

Characteristics

MAP

MSAP

SAP

P 1

P 2

P 3

No. of patients

200

110

65

   

Age, year

51.36 ± 13.95

52.06 ± 14.22

53.79 ± 15.64

0.681

0.236

0.441

Male sex, n (%)

118 (59.0)

68 (61.8)

44 (67.7)

0.628a

0.212a

0.434a

Etiology, n (%)

   

0.137a

0.278a

0.885a

   Gallstones

152 (76.0)

75 (68.2)

45 (69.2)

   

   Other

48 (24.0)

35 (31.8)

20 (30.8)

   

Smoking habit, n (%)

56 (28.0)

36 (32.7)

25 (38.5)

0.383a

0.112a

0.442a

BMI, kg/m2

24.11 ± 4.55

24.42 ± 4.68

24.87 ± 4.83

0.574

0.252

0.536

WBC, ×109/L

12.24 ± 4.98

12.68 ± 5.15

13.05 ± 5.55

0.471

0.270

0.645

Neutrophil, ×109/L

9.11 ± 3.75

11.25 ± 4.34

13.47 ± 6.08

<0.001

<0.001

0.001

Lymphocyte, ×109/L

1.06 ± 0.66

1.10 ± 0.62

0.99 ± 0.74

0.612

0.460

0.290

RBC, ×109/L

4.72 ± 0.71

4.65 ± 0.70

4.58 ± 0.63

0.396

0.159

0.520

HGB, g/L

143.45 ± 27.33

141.21 ± 25.15

138.50 ± 24.52

0.521

0.230

0.543

PLT, ×109/L

187.65 ± 66.24

182.39 ± 62.71

176.74 ± 63.15

0.494

0.237

0.575

CRP, mg/L

71 (18–126)

145 (96–237)

212 (158–356)

<0.001 c

<0.001 c

<0.001 c

ALT, U/L

98 (5–831)

106 (10–883)

113 (12–1055)

0.514c

0.309c

0.665c

AST, U/L

125 (15–921)

133 (21–835)

129 (20–847)

0.599c

0.827c

0.842c

LDH, U/L

262.29 ± 150.75

323.84 ± 162.38

455.93 ± 204.65

0.002

<0.001

<0.001

Glucose, mmol/L

7.98 ± 4.23

8.22 ± 4.67

9.43 ± 4.88

0.652

0.024

0.085

ALB, g/L

37.53 ± 6.36

35.19 ± 5.77

33.26 ± 5.45

0.002

0.001

0.046

Amylase, U/L

524 (56–3146)

685 (89–3313)

892 (84–3607)

0.037 c

<0.001 c

0.042 c

BUN, mmol/L

4.44 ± 1.68

4.83 ± 1.74

5.99 ± 2.92

0.096

<0.001

<0.001

Calcium, mmol/L

2.17 ± 0.27

2.09 ± 0.25

2.01 ± 0.30

0.013

0.002

0.059

TC, mmol/L

3.86 ± 1.90

4.05 ± 2.12

4.08 ± 2.14

0.426

0.444

0.924

TG, mmol/L

2.98 ± 1.81

3.64 ± 2.78

4.26 ± 3.07

0.020

0.001

0.096

HDL-C, mmol/L

1.29 ± 0.26

1.25 ± 0.31

1.17 ± 0.29

0.231

0.003

0.069

LDL-C, mmol/L

2.95 ± 1.45

3.21 ± 1.69

3.12 ± 1.43

0.151

0.434

0.706

ApoA1, g/L

1.10 ± 0.46

1.12 ± 0.51

0.95 ± 0.43

0.720

0.026

0.021

ApoB, g/L

0.72 ± 0.48

0.88 ± 0.50

0.96 ± 0.61

0.009

0.001

0.317

ApoB/A1 ratio

0.66 ± 0.41

0.81 ± 0.43

1.02 ± 0.62

0.006

<0.001

0.004

APACHE II score (at 24 h)

4.0 (3.0–6.0)

9.00 (4.0–10.0)

13.0 (8.0–19.0)

<0.001 c

<0.001 c

0.001 c

Ranson score (at 48 h)

2.0 (1.0–2.0)

4.0 (2.0–6.0)

5.0 (4.0–7.0)

<0.001 c

<0.001 c

0.056c

BISAP score

1.0 (0.0–1.0)

1.0 (1.0–2.0)

2.5 (2.0–3.0)

0.847c

<0.001 c

<0.001 c

MCTSI score

2 (1–3)

5 (2–7)

6 (4–8)

0.002 c

<0.001 c

0.528c

Hospital stay, days

8 (6–13)

23 (11–33)

41 (22–64)

<0.001 c

<0.001 c

<0.001 c

Intensive care unit, n (%)

15 (7.5)

42 (38.2)

51 (78.5)

<0.001 a

<0.001 a

<0.001 a

28 days mortality, n (%)

0 (0.0)

1 (0.9)

10 (15.4)

0.355b

<0.001 b

<0.001 b

  1. Continuous variables are described as means ± standard deviations (normal distribution) or median and interquartile range (abnormal distribution). Categorical variables are described as N (%).
  2. Notes: P1, MAP vs. MSAP; P2,MAP vs. SAP; P3, MSAP vs. SAP.
  3. aStatistical results based on χ2 analysis; bStatistical results based on Fisher’s exact test; cStatistical results based on Kruskall-Wallis test; the others were based on one way variance analysis and least-significance difference t test.
  4. MAP, mild acute pancreatitis; MASP, moderately severe acute pancreatitis; SAP, severe acute pancreatitis; BMI, body mass index; WBC,white blood cell; RBC, red blood cell; HGB, hemoglobin; PLT,platelets; CRP, C-reactive protein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; ALB, albumin; BUN, blood urea nitrogen; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoB/A1 ratio, apolipoprotein B-to-apolipoprotein A1 ratio; APACHE II, acute physiology and chronic health evaluationII; BISAP, besides index for severity in acute pancreatitis; MCTSI, modified computed tomography severity index.
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