Table 1 Comparison of our custom-designed microfluidic chips and traditional HTS methods.
From: A novel anti Candida albicans drug screening system based on high-throughput microfluidic chips
Microfluidic chips | Traditional HTS Methods (384w-MTP as example)39 | |
|---|---|---|
Principle | Direct living cells counting | AlamarBlue Redox method, or 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method40,41, Indirect method |
Quantity | 100 kinds of drug | 20 kinds of drug |
Operation time for 50520 drugs screening | 1 week | 125 days |
Observation | Visually, intuitively | Indirectly |
Reagent | Totally <1 μL | >100 μL/well |
