Figure 7 | Scientific Reports

Figure 7

From: Design, synthesis, and discovery of novel oxindoles bearing 3-heterocycles as species-specific and combinatorial agents in eradicating Staphylococcus species

Figure 7

Analysis of the specificity of active compounds on Gram-positive and -negative strains. (A) Antibacterial activity of KS15, KS16, KS17, KS19, KS20, and chloramphenicol, methicillin, and streptomycin. The activity was determined with different concentrations of compounds against Gram-positive S. epidermidis (ATCC 12228) (left) and S. saprophyticus (ATCC 15305) (right). (B) Determination of MIC of compounds. Values indicated were averaged from n = 5. (C) Evaluation of antibacterial activity against Gram-negative species. The growth of E. coli (ATCC 25922) and P. aeruginosa (ATCC 27853) with different concentrations of KS15, KS16, KS17, KS19, KS20, chloramphenicol, methicillin, and streptomycin was depicted. Images of 96-wells for individual compounds with indicated concentrations were photographed. In (A,B) one of the representative images from n = 5 were processed in Adobe Illustrator CS6 (v16.0.0, Adobe Systems Inc., USA).

Back to article page